Long term cardiovascular sequelae of severe thermal trauma

Research Group long term cardiovascular sequelae of severe thermal trauma

Recent scientific findings indicate, that a severe burn injury is associated with impaired heart function, altered myocardial structure and reduced maximal cardiovascular exercise tolerance even long after the initial trauma is resolved. In a pilot study on young adults who had survived a severe pediatric burn at least 5 years prior, we were able to show that systolic and diastolic cardiac function were reduced and that a fibrotic remodeling of myocardium had occurred; in these patients, maximal exercise tolerance was significantly lower than in healthy controls. It is the aim of our research group to investigate and further describe the pathophysiology and mechanism of this phenomenon in translational preclinical and clinical studies, in order to develop preventive or therapeutic concepts for current and future patients. Inherent is a particular importance in light of an ever-growing cohort of burn survivors due to massive improvements in acute burn care over the last decades. This process is paralleled by an increasing interest in the long term outcomes of burn survivors. 

 Projects
  • Short- and longterm burn-induced cardiovascular alterations in an animal model
  • Observational clinical study of longterm sequelae of severe burn injury
  • Obersavational clinical study of longterm sequelae of severe pediatric burn injury
 Cooperation partners
  • Prof. Dr. Patrick Most, Dr. Martin Busch, Sektion für Molekulare und Translationale Kardiologie, Innere Medizin III, Universitätsklinikum Heidelberg
  • Michael P Kinsky MD, Ludwik K Branski MD & David N Herndon MD FACS, University of Texas Medical Branch and Shriners Hospital for Children Galveston, Texas, USA
 Publications
  • Hundeshagen G, Herndon DN, Clayton RP, Wurzer P, McQuitty A, Jennings K, Branski LK, Collins VN, Ribeiro Marques N, Finnerty CC, Suman OE, Kinsky MP. Long-term impact of critical illness on cardiac function in pediatric burn survivors – an observational study. The Lancet Child and Adolescent Health, 2017.
  • Hundeshagen G, Wurzer P, Herndon DN. Life-long relationships? The future of pediatric burn care and research. Burns. 2017.
  • Cambiaso-Daniel J, Rivas E, Carson J, Hundeshagen G, Nunez-Lopez O, Glover S, Herndon DN, Suman OE. Cardiorespiratory capacity and strength remain attenuated in severely burned children at over 3 years postburn. The Journal of Pediatrics, 2017.
  • Elhoff JJ, Shekerdemian LS. The slow burn: are we neglecting potential long-term cardiovascular sequelae of critical illness in children?. The Lancet Child & Adolescent Health. 2017 Dec 1;1(4):254-6

  Head of the research group long term cardiovascular sequelae of severe thermal trauma

Dr. med. Gabriel Hundeshagen MMS

gabriel.hundeshagen@bgu-ludwigshafen.de

  Deputy Head of the research group long term cardiovascular sequelae of severe thermal trauma

Prof. Dr. med. Christoph Hirche

christoph.hirche@bgu-ludwigshafen.de